Numerical analysis of thermal damage and oxygen distribution in laser irradiated tissue

A numerical analysis of the thermal damage process that proceeds in biological tissue during laser irradiation is presented. Heat transfer in the tissue is assumed to be transient and two-dimensional. The internal heat source resulting from the laser irradiation based on the solution of optical diffusion equation is taken into account. Changes in tissue oxygen distribution resulting from temperature changes are analyzed using the Krogh cylinder model with Michaelis-Menten kinetics. A Hill model was used to describe the oxyhemoglobin dissociation curve. At the stage of numerical realization, the boundary element method and the finite difference method have been applied.