Badania laboratoryjne nad pełzakobójczym działaniem Entizolu (metronidazolu produkcji Polfa)

The aim of the studies was to obtain some more accurate data on the amoebicidal effect of Entizol (Polfa) both on experimental E. histolytica infections and on the in vitro growth of the amoebae. The in vitro experiments were performed on four E. histolytica strains (two virulent and two avirulent); thr minimal amoebicidal concentrations of Entizol were higher from concentrations of Flagyl (Specia) and similar to the concentrations of emetine hydrochloride (Burroughs Wellcome a. Co.). In experiments in vivo, rats and guinea-pigs were infected parallelly with two virulent strains of E. histolytica; in the control of experimental amoebiasis, Entizol was as patent as Flagyl and mme effective than emetine hydrochloride.