Aktywność leków azolowych in vitro wobec szczepów Candida albicans o różnych kodach wyodrębnionych z przewodu pokarmowego dzieci

The activity of ketoconazole (K, R04 1400 molecular weight 531.44), miconazole (M, RO1 4889, molecular weight 479.15) and itraconazole (I, ROS 1211, molecular weight 705.64) obtained from Janssen Pharmaceutica NV, against Candida albicans strains was studied. The axenic fungal strains were isolated from the faecal samples of children — not previously treated with antifungal drugs — with clinical symptoms suggesting the inflammation of the mucous membrane in the stomach and/or duodenum. The strains were assessed by own methods and unified tests (bioMérieux: API 20 C, API 20 C AUX). Five codes of Candida albicans Berkhout were found. The minimal inhibitory concentration (MIC) values were calculated from 448 dose-response curves according to the agar diffusion —- Kadtubowski’s method. MICs were also examined by analyzing the variation (min-max, x mean + standard error, mode Mo, median Me). It was demonstrated that all the strains used in the study were susceptible to the azoles drugs.