The cooperation of scientists specializing in different fields has given rise to the
integration of previously distinct thematic areas and creation of new multidimensional
disciplines as a result. Biochemistry, which has derived from the borderline of
chemistry and biology, can be set as a good example. In this short review an insight
into electrochemical studies, which are currently carried out in the Department of
Microbioanalytics at the Faculty of Chemistry (Warsaw University of Technology),
was presented. Three independent scientific pathways introducing electrochemical
methods for biochemical and bioanalytical purposes can be distinguished among
the ongoing researches.
The first one embraces the design of the so-called electronic tongue – a system
used for the qualitative and quantitative analysis of liquid samples of complex
composition. In this work, potentiometric sensor arrays were applied to develop
an electronic tongue system enabling the evaluation of the effectiveness of bitter
taste masking of pharmaceuticals. The second scientific pathway involves voltammetric
studies of the interactions of biologically active peptides with copper(II) ions.
The interest was drawn to clarify and describe the role of β-amyloid and NSFRY
copper(II) complexes, relevant to Alzheimer’s disease occurrence and cardiovascular
system disorder respectively. Finally, boronic acids and their derivatives, exhibiting
the affinity for molecules possessing 1,2 or 1,3-diol group in their structure,
were used as selective molecular receptors in the third research project. The studies
include the selection of the optimal method and conditions of the immobilization
process, providing the most favorable receptor layer structure, and the determination
of the performances of constructed electrochemical sensor towards particular
bioanalytes.
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