Stabilized bovine pericardium (BP) belongs to tissues routinely applied in production of heart valves. Commercial
products are manufactured from tissues crosslinked by glutaraldehyde (GA). Dye-mediated photooxidation was
also proposed as an alternative method, which allows for the elimination of clinical failures of GA-treated tissues. The
aim of the study was to investigate the density of BP stabilized by GA and the methylene blue-mediated photooxidation,
as compared with a native tissue. Crosslinking density was evaluated based on their ability to accumulate radioactive
cobalt ions (60Co2+) and the permeability to these ions. Radioactivity was examined using a γ-spectrophotometer
(Packard). The results showed the changes in the crosslinking density between the native tissues and photooxidized or
GA-crosslinked tissues. Significant decreases in radioactivity were detected only in the thinnest tissues after photooxidation
and in filtrates penetrating the same samples. Photooxidized pericardium of a larger thickness did not reveal
any significant changes. Weight-dependence for the permeability was observed in the case of filtrates penetrating the
GA-treated tissues. However, 60Co2+-accumulation in these samples remained at the same level. Photooxidation may
lead to obtaining biomaterials with advantageous properties, i.e. a decreased calcium-binding capacity. Photooxidation
efficiencies were dependent both on compactness and thickness of tissues and on process duration. It should
be emphasized that the tissues’ structure after photooxidation was characterized by lower density. This may point to
the presence of crosslinks of a smaller compactness in comparison with GA treatment. It has been shown that the factor
indeed influencing the result of crosslinking is tissue thickness.
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