The Fricke xylenol orange (FX) gel system is a chemical dosimeter characterized by good sensitivity,
linear dose response, tissue equivalence, no toxicity, easy preparation, reproducibility and low cost. Thanks to the
presence of the gelatinous matrix, the system is particularly suitable to perform reliable 3D mapping of the absorbed
dose spatial distribution via magnetic resonance imaging (MRI) or optical techniques. The aim of this work is to
study in a systematic way the influence of the pre-irradiation storage procedure upon sensitivity, dose response
stability and lifetime of use of a FX gel system made with gelatin from porcine skin subjected to homogeneous
irradiation. For this purpose, different pre-irradiation storage procedures, in terms of temperature and duration
of each storage step, were investigated. In order to evaluate the dose response stability, the optical analyses of the
samples were performed up to 6 hours after irradiation. Moreover, the samples were irradiated at time intervals
of 24 hours for up to 7 days after preparation in order to evaluate the system lifetime of use. Regardless of their
thermal and temporal life, the samples show linear dose responses in the investigated dose range (3–24 Gy) and an
increase of sensitivity with the time elapsed between preparation and irradiation. Among the three pre-irradiation
storage procedures considered here, a procedure that provides the best dose response stability and lifetime of use
was identifi ed and recommended for further use. The analyzed dosimetric system possesses good properties that
make it promising for medical application, particularly concerning the evaluation of pre-treatment plan quality
assurance within the conformational external beam radiotherapy.
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