Controlling the mean arterial pressure by modified model reference adaptive controller based on two optimization algorithms

This paper Presents Modified Model Reference Adaptive Controller (MRAC) to regulate the hight blood pressure. It is based on slate model that repre-sent the mathematical equation that clarifies relationship between blood pressure and vasoactive drug injection. In this work Squirrel Search Algo-rithm (SSA) and Grey Wolf Optimizer (GWO) algorithms are considered to optimize the controller parameters. the results showed that the suggested controller has good performance and stabilize the mean arterial pressure with small settling time (below than 400s) and small overshoot (below than 1 mmHg) with low amount of error.