Preparation of silver core nanoparticles with polysaccharide shell

The objective of the present study was to obtain silver core nanoparticles coated with dextran shell. In the described method dextran plays role of reductive and protective agent and also functionalisation ligand. Our research was aimed at nanoparticles synthesis at 37°C. It is the human body temperature, which is safe for temperature-sensitive drugs (proteins). In the presented work the time of reaction, dextran molecular weight and its chemical functionalisation was investigated. Particles were characterized by Nanosight and SEM, their UV–Vis spectroscopic absorption properties were also determined. Nanoparticles with diameter less than 95 nm with relatively narrow size distribution were obtained. Our work demonstrated that it was possible to obtain nanoparticles in 37°C without using any harmful reagents.