Painkiller drugs or analgesics are potent pain reliever chemical agents, which are
commonly used in pain therapy. Mathematical modeling by QSAR (quantitative structure activity
relationship) methods are well known practices to determine predictive toxicity in biota. Now-adays,
an easy screening of chemicals, QSAR can be done by using several recommended softwares.
The present study was carried out by using software namely T.E.S.T. (Toxicity estimation software
tool) for rat oral LD50 (median lethal dose) predictive toxicity for common painkiller drugs. These
painkiller drugs were selected as 35 compounds and tabulated on the basis characteristics of one
non-narcotic viz. acetaminophen, twenty non-steroidal anti-inflammatory such as bromofenac,
diclofenac, diflunsial, etodolac, fenoprofen, flurbiprofen, ibuprofen, indomethacin, ketoprofen,
ketorolac, maclofenamate sodium, mefenamic acid, meloxicam, nabumetone, naproxen, oxaprozin,
phenylbutazone, piroxicam, sulindac and tolmetin as well as fourteen narcotic viz. buprenorphine,
butorphanol, codeine, hydrocodone, hydromorphone, levorphanol, meperidine, methadone,
morphine, nalbuphine, oxycodone, pentazocine, dextropropoxyphene and tapentadol. The data were
tabulated on experimental (bioassay) from ChemIDPlus and T.E.S.T. and predictive toxicity of 30
compounds out of 35 compounds by using T.E.S.T. The predictive data were found by T.E.S.T. that
20 and 10 compounds were very toxic and moderately toxic respectively but not extremely, super
toxic and non-toxic in rat model after acute oral exposure. It is suggested to evaluate the predicted
data further with other available recommended softwares with different test models like daphnia,
fish etc. to know aquatic toxicity when these compounds may discharge into waterbodies.
Ta witryna wykorzystuje pliki cookies do przechowywania informacji na Twoim komputerze. Pliki cookies stosujemy w celu świadczenia usług na najwyższym poziomie, w tym w sposób dostosowany do indywidualnych potrzeb. Korzystanie z witryny bez zmiany ustawień dotyczących cookies oznacza, że będą one zamieszczane w Twoim komputerze. W każdym momencie możesz dokonać zmiany ustawień dotyczących cookies
Informacja
SZANOWNI CZYTELNICY!
UPRZEJMIE INFORMUJEMY, ŻE BIBLIOTEKA FUNKCJONUJE W NASTĘPUJĄCYCH GODZINACH:
Wypożyczalnia i Czytelnia Główna: poniedziałek – piątek od 9.00 do 19.00