Synthesis and biological activity of pyrazole and 1,2,3-triazole containing heterocyclic compounds

As heterocyclic compounds show good biological activity, we have synthesized nitrogen containing compounds among them 9a, 9c, 9e and 9f have shown very good antimicrobial activity with remarkable inhibition zones. N'-((5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)methylene)-5-methyl-1-phenyl-1H-1,2,3-triazole-4-carbohydrazide (9a-i, 10) was synthesized from 5-(aryloxy)-3-methyl-1-phenyl-1H-pyrazole-4-carbaldehyde and 5-methyl-1-phenyl-1H-1,2,3-triazole-4-carbohydrazide by condensation in acidic media. 5-(aryloxy)-3-methyl-1-phenyl-1H-pyrazole-4-carbaldehyde and 5-methyl-1-phenyl-1H-1,2,3-triazole-4-carbohydrazide were synthesized from phenyl hydrazine and substituted anilines respectively. All intermediates and final compounds were confirmed by 1H-NMR, 13C-NMR, Mass Spectroscopy methods and compound 9c was confirmed by single XRD analysis.