The role of angiogenesis in the pathogenesis of external genital endometriosis

The study is aimed to assess the role of angiogenesis in the pathogenesis of external genital endometriosis. This study was conducted in the gynecological clinics of the Clinical Military Medicine Center of the Southern region of Ukraine (Odessa, Ukraine). There were examined 215 patients of reproductive age (30,2±0,9 years). These patients were distributed in 2 clinical groups: 94 patients with the external genital endometriosis and 81 with adenomyosis. The control group was presented by 40 healthy females of the same age (29,7±0,5 years). The clinical examination was conducted accordingly to the clinical guidelines recommended by the PHMU orders № 620 and 676 There were 14 (14,9%) patients of I group with IV stage of the external genital endometriosis, 33 (35,1%) – with III stage and 47 (50,0%) with the mild manifestations of the disease. The infertility occurs amongst 27.7% of the patients. In the second group the majority of patients have I-II stage of adenomyosis (54.3%). The concentration of VEGF in the peritoneal fluid was highly variable (23.1±1.3 ng/ml) and was correlated with the severity of endometriosis lesions (r=0,61 p<0,05)