Synthesis, biological investigations, QSAR and DFT analysis of sulfonamide chalcones as potential: antimicrobial, antifungal and antimalarial agents

Various aromatic aldehydes condense with aryl ketone (N-(4-(phenylsulfonamido)phenyl) acetamide) in presence of aqueous alkaline NaOH to form α, β-unsaturated ketone (N-(4-(N-phenylsulfamoyl)phenyl)cinnamamide derivatives or sulfonamide chalcone derivatives). We were synthesized novel sulfonamides chalcones synthesized through Claisen-Schmidt condensation of aromatic aldehydes and sulfonamide containing acetanilide. All the synthesized compounds were characterized using Mass, FTIR, NMR (1H & 13C) spectra analysis. The synthesized sulfonamide chalcone hybrids were screened antimicrobial activity, antifungal and antimalarial activity.