Próby leczenia rzęsistkowicy pochwy za pomocą nowych N-chlorowco-amidów kwasu p-azobenzenosulfonowego i benzenosulfonowego

Potassium and Lithium N-chloramide-p-azobenzenosulphonate and sodium N-chloramide benzenosulphonate (synthesized at the Department of Organic Chemistry, Łódź University, under the direction of Prof. Dr. A. Chrząszczewska) were used to treat trichomonadosis of the vagina, after the elimination of extravaginal invasion foci. At the preceding Symposium the preliminary results were reported which point to strong trichomonacidal properties of these compounds in vitro. Totally, 143 women were treated by the administration of 0.05% solutions of the compounds and of globules in cocoa butter containg 0.05 g of the substance. For 15 days the treatment consisted in vaginal cleansings with fresh compound solutions (in boiled water) and application of l globule overnight; 123 (84.6%) patients were regarded as cured in whom the 3-month follow-up examination showed no T. vaginalis. The differences in the percentage of cures following the use of potassium and lithium N-chloramide-p-azobenzenosulphonate (80%) and sodium N-chloramide benzenosulphonate (p > 95%) were not statistically significant.