Epilepsy is a common neurological disorder. It affects 50 million people worldwide, over
half of which are children. Many children who suffer from epilepsy are also affected by
metabolic disorders, characterized by obesity as well as intolerance and deficient transport
of glucose. Recently, many researchers have indicated chromium (+3) as an essential trace
mineral which probably plays an important role in metabolism of glucose and insulin. There
are no data about chromium alterations in the body of epileptic patients. The purpose
of this study was to find possible correlation between chromium (+3) concentration and
the glucose level in children with epilepsy. Material and methods: Twenty-three untreated
epileptic children with idiopathic generalized tonic-clonic seizures (9 girls and 14 boys) aged
13.4±2.7 years and 25 healthy children (sex-age-matched) served as a control were recruited
to this study. The chromium blood and serum concentrations were determined as well
as serum glucose level. Results: There were no statistically significant differences between
epileptic and healthy children in the mean chromium (+3) blood concentration as well as
according to sex in both analyzed groups of children. The mean serum chromium concentration
in epileptic children was significantly lower than in healthy subjects generally
(p<0.001), as well as in boys group (p<0.001) and girls (p<0.001). Although, the negative
statistically significant correlation between serum glucose and chromium concentrations
was found in epileptic children (p<0.01), we have not found so associations in whole blood
and in healthy children. Conclusions: Our research has shown that during epilepsy the
concentration of serum chromium was lower than in healthy subjects what was associated with glucose abnormalities. These preliminary results suggest that the detail research on
the chromium in epilepsy are necessary.
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