Despite continuous scientific and technological advances in MR imaging, MR perfusion methods have not yet been widely
deployed for routine clinical diagnostics. This is especially true for ASL (arterial spin labelling) methods used to evaluate cerebral
perfusion. This method does not require a contrast agent, as new discoveries about gadolinium accumulation in the cerebellum
and brain nucleus appear to be a valuable asset and provide the opportunity to be more widely deployed in clinical practice. The
aim of this paper is to present the historical determinants of the development of MR perfusion techniques, the disadvantages
and advantages and possible clinical applications and prospects of ASL development. Both historical articles published on MR
in the 1990s and current research between 2006-2016 have been reviewed. The authors present in the work the MR perfusion
method focusing on issues related to arterial spin labeling (ASL). Historically CASL (continuous ASL) and PCSL (pulsed ASL)
techniques have been described and the pseudocontinuous ASL (pseudocontinuous ASL) 3D technique presents its technical
and methodological considerations, advantages and disadvantages over previous methods. The methods of test protocol
optimization and accompanying artifacts, as well as possible clinical applications and development perspectives, have been
described.
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