Fabrication of novel material with athrombogenic potential: Immobilization of peptides on polyurethane surface

Presented study was undertaken to fabricate a hemocompatible material that could be a potential candidate for use in fabrication of blood-contacting devices, e.g. circulatory support devices, vessel grafts, heart valves. The final material could be used as a scaffold for endothelial cell growth and initiate in situ endothelialisation. The newest and most promising strategy in material endothelialization involves introduction of short peptide sequences that can selectively address one particular type of cell adhesion receptors and promote cell adhesion. Thus, the aim of work was to elaborate a method of immobilizing peptides specific for integrins onto polymer substrate.